Utilizing melt extrusion technology

Hot Melt Twin Screw Extruder

Hot melt extrusion technology was originally developed by the plastics industry and is now emerging as a novel drug delivery technology, creatively integrating processing techniques with pharmaceutical science for drug delivery research. It is mainly used to enhance the dissolution of poorly soluble drugs and to prepare sustained or controlled release for-mulations.

Drug Delivery
Polymer Materials
Food Industry

WST hot melt extrusion system—customized

Pelletizer

Feeder

Conveyor Belt

  1. Rotary knife material: 440C
  2. Adjustable speed: 0–300 rpm
  3. Number of hob blades:12
  4. PLC control panel
  1. Power: 0.4 kW
  2. Power supply: 220V 50Hz
  3. Standard hopper: 2L
  4. Servo motor speed control
  5. Bottom scraping; fully detachable for offline cleaning
  1. Conveyor belt: Tefon-coated
  2. Speed control motor power:6W
  3. Belt speed: 0–1 m/s
Model ZE-9 ZE-12 ZE-16 ZE-22
Output 0-0.8kg/h 0-1.5kg/h 0-3kg/h 3-10kg/h
Rotational speed 0-300rpm 0-225rpm 0-225rpm 0-600rpm
Minimum single-batch throughput 10g 15g 20g 50g
Maximum working pressure 30bar 40bar 40bar 60bar
Maximum torque per individual screw ≤9N.m ≤14N.m ≤18N.m ≤86N.m
Screw length-to-diameter ratio 1:10 1:10 1:24 1:28-40
85%

Product Quality Index

92%

Energy Generation

Why choose co-rotating twin-screw extruders?

  • High speed (0–450 rpm)

  • High shear and mixing capability

  • Self-cleaning

  • No compression efect between co-axial screws

  • Integrated melting, mixing, venting, and reaction

  • Design/manufacturing

Small-pitch screw element

Large-pitch screw element

Shear element

The basic structure of typical hot-melt extrusion screw elements includes:

Interchangeable modular thread elements enable flexible processing while reducing production time and costs.

The barrel is integrally formed, and the screw is mirror-polished with no dead zones, fully meeting GMP requirements.

Equipped with a GEFRAN digital melt pressure gauge and integrated temperature control probes for fully automated system pressure control.

Equipped with a GEFRAN digital melt pressure gauge and integrated temperature control probes for fully automated system pressure control.

Composed of an MCH ceramic heater, PID with PT100 sensors, and a SIEMENS S7-200Smart PLC, integrated as one system, heats the final material to reach a molten state.

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Industries We Support Industries We SupportIndustries We Support Industries We Support

Pharmateucial

This technology can process polymer materials above their glass transition temperature, enabling thermoplastic binders and/or polymers and active ingredients to be effectively mixed at the molecular level.

Drug in solid dispersion system

Enhances dissolution of poorly soluble drugs

Drug in solid dispersion system

Drug in solid dispersion system

PLGA carrier: dissolution profile of long-acting formulations prepared by hot melt extrusion,Dissolution medium: USP pH 7.4 (Ibuprofen, Tramadol Hydrochloride, Dexamethasone, Diazepam)

Classic drug repurposing: Azithromycin dry suspension.At 10% drug loading (w/w), there is no bitterness detected in the absence of sweeteners

Food Processing

Its application in the food industry has been steadily increasing in recent years. By using high temperature, high pressure, and shear forces, raw materials are mixed, melted, and extruded, offering benefits such as high efficiency, continuous production, and no solvent residue.

Functional food processing

Lipid and favor modulation

Plant-based meat